Insulin resistance is a central feature of T2DM and is the primary target for therapy. Nevertheless, the pathological consequences of T2DM predominantly relate to cerebro- and cardiovascular disease (CVD), representing the leading cause of morbidity and mortality in T2DM. Up to 60% of all deaths in T2DM are directly related to CVD, whilst patients with T2DM develop microvascular complications (e.g. retinopathy, nephropathy and neuropathy).
During the last years a great scientific focus has been on the potential implications of exposure to hyperglycemia during pregnancy for long-term adiposity and cardio-metabolic outcomes in the offspring.
Pages
